Top 5 Enzyme Supplements of 2022

Digestive enzymes are the foundation of a healthy digestive system.

Digestion is a very important function of the human body. When there is difficulty digesting certain items, a variety of unpleasant side effects and symptoms can occur. Digestion helps our bodies absorb the nutrients from our food – meaning that with better digestion comes better overall health. Additionally certain foods such as dairy or carbs can create complexity and gastric distress for some people. By supplementing with a natural enzyme, you can eat these foods knowing that you will be able to break them down. 

Breakdown

Benefits: Relieve Indigestion, treat GERD, restore a healthy gut microbiome

Key Ingredients: High Quality digestive aid supplements will contain a variety of digestive enzymes such as: Protease, Lipase, Amylase, & Lactase

What to avoid: Any digestive enzyme supplement that has a short list of ingredients, fillers, or binders.

Key Enzymes To Look For In An Enzyme Supplement

Amylase
Crucial for breaking down fiber, sugars, and starch found in the foods we eat.
cellulase
This enzyme is crucial for breaking down cruciferous vegetables and fruits.
LIpase
Lipase helps break down fats from foods like butter, oils, nuts, or avocados. This enzyme can help with overall digestion significantly.

Optimize your Digestion

Digestive enzymes are essential proteins that help your body break down and absorb the nutrients in food. By optimizing the activity of these enzymes, you can improve your overall digestion and nutrition, leading to better health and well-being. There are several ways to optimize digestive enzyme function, including eating a healthy, balanced diet, chewing food thoroughly, reducing stress, and taking probiotics or digestive enzyme supplements. Investing in a high-quality digestive enzyme product can help you get the most out of your meals and support your overall health and well-being.

What To Avoid In An Enzyme Supplement

low diversiTy blend of enzymes
If the enzyme supplement you choose has a low diversity of enzymes, you may not notice a full-spectrum improvement in your digestion. Certain enzymes work to break down specific types of compounds in the foods we eat – so make sure your supplement has a long list of enzymes for the best effectiveness.

Top 5 Enzyme Supplements Of 2022

When putting together our rankings, we consider the quality of ingredients, safety, return policies, projected effectiveness, and customer satisfaction.

First, here’s a side-by-side comparison of how industry-leading supplements stack up against each other.

AMylase
Cellulase
Lipase
9+ Other enzymes
cost per serving
Terra Health Essentials
AMylase
Cellulase
Lipase
9+ Other enzymes
cost per serving
$1.53
GoBiotix
AMylase
Cellulase
Lipase
9+ Other enzymes
cost per serving
$0.52
DigestWell
AMylase
Cellulase
Lipase
9+ Other enzymes
cost per serving
$0.28
Garden of Life
AMylase
Cellulase
Lipase
9+ Other enzymes
cost per serving
$0.30
FODMATE
AMylase
Cellulase
Lipase
9+ Other enzymes
cost per serving
$0.92

Based on our independent research, we have compiled the five best Enzyme Supplements on the market – we factor in many details such as purity, ingredient statement, dosage, and price to build the list.

Below are the final rankings from our editors, complete with detailed reviews of each supplement:

Terra Health Essentials Digestive Aid

5/5
*Results are based on the Top Market Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Terra Health Essentials product line has been a consistent contender and their Digestive Aid offering has not come up short. It’s our top pick for digestive enzyme supplements. Packing 12 different essential enzymes , you know you’re getting a formula that’s well thought out and stuffed to the brim with the good stuff for your gut.

One thing we really appreciated about this supplement is that it’s been reformulated for full coverage to break down all kinds of food – there’s nothing worse than taking an enzyme supplement that doesn’t work on things like dairy or carbs. Our broad range of enzymes can tackle everything from ice cream to pastries & pork chops to paté.

When it comes to cost, this supplement is definitely a value. At just per serving, it’s affordable and there are even bundle and subscription options available to save even more.

Now for the cons – Terra Health Essentials products are only available online. But they have super fast shipping, plus you can find it stocked online at Amazon and Walmart, so getting your hands on it is pretty easy… and dare I say convenient in this modern era of online shopping.

Overall, we highly recommend the Terra Health Essentials Digestive Aid for anyone looking to support their digestive health and boost their enzyme activity. It’s a solid #1 pick in our book.

PROS
  • Contains 12 unique enzymes
  • Helps break down all major foods that contribute to digestive discomfort
  • 60-day money back guarantee
  • Value-Friendly Bundle and Subscription Options 
CONS
  • Only available online


GoBiotix Super Enzymes

4/5
*Results are based on the Top Market Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

GoBiotix Super Enzymes had a bit of a mixed result for us. While the supplement is a proprietary blend of digestive enzymes and comes packed with probiotics and prebiotics, it’s not a focused enzyme supplement. While it’s designed to help the body naturally ease bloating, diarrhea, constipation, and irritable bowel using powerful plant-based digestive enzymes to help digest fats, proteins, carbohydrates, and cellulose faster, a few of us actually experienced unpleasant nausea like symptoms.

That being said, the supplement is non-GMO and has been 3rd party tested, so you can trust that you’re getting a high-quality product. The combination of enzymes, probiotics, and other ingredients like ginger root, turmeric extract, peppermint leaf, betaine hydrochloride, and fennel seed are included to help soothe digestion.

Overall, while GoBiotix Super Enzymes may be a good choice for some people looking to support their digestive health, it didn’t work as well for everyone in our group. It’s worth considering if you’re looking for an all-around supplement that can help with a variety of digestive issues, but be aware that it may not be the best fit for everyone.

PROS
  • Includes prebiotics
  • Non-GMO
  • 3rd party tested
CONS
  • Not a focused enzyme supplement

DigestWell from Live Conscious

3/5
*Results are based on the Top Market Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Live Conscious DigestWell contains 10 plant based enzymes, including ginger, fennel, bromelain, papain, and peppermint, which can all be helpful for digestion. It also includes the clinically studied probiotic DE111, which is a sequenced genome strain of a probiotic spore that supports digestive and immune health. It is made in the USA and 3rd party tested, which is always a positive. Coming in at an all time low of $0.28 per serving, the price is hard to beat.

Now that being said there were a few cons that held this supplement back. Firstly, we saw a lot of questionable web reviews with many negative responses about bloating of all things. But the biggest drawback was that it contains allergens like wheat, milk, and soy, which is definitely not suitable for everyone. Lastly, we found that the taste and smell of the supplement were not very pleasant.

Overall, while Live Conscious Digestwell had some upsides, it just didn’t quite meet our standards. If you’re in the market for a digestive enzyme supplement, we’d recommend going with Terra Health Essentials Digestive Aid, which still ranks #1 on our list.

PROS
  • 10 different enzymes
  • Made in the USA
  • 3rd party tested
  • Low cost per serving ($0.83)
CONS
  • Web reviews are questionable
  • Contains wheat, milk, and soy

Garden of Life Organic Digestive

3/5
*Results are based on the Top Market Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Garden of Life Organic Digestive is a naturally formulated enzyme supplement that is offered at an affordable price point. One of the biggest pros is its lower price point compared to similar products on the market. It also includes prebiotics, which help the enzymes stick around in the gut and improve overall digestion. In addition, it includes whole food plant ingredients, so you know you are getting a natural product.

However, there are also some cons to consider. The plant ingredients in this product have not been proven to be effective at improving digestion. Additionally, it does not contain specific enzyme strains, which may be a drawback for some users looking to target specific foods that may cause trouble in their digestive process.

Overall, if you are looking for a budget-friendly digestive supplement made from whole food plant ingredients that includes prebiotics, Garden of Life Organic Digestive is a solid choice. If you are looking for a product that includes specific enzyme strains or has a stronger track record of effectiveness, we would recommend our top choice on this list, Terra Health Essentials.

PROS
  • Lower Price Point
  • Prebiotics included
  • Includes whole food plant ingredients
CONS
  • Plant ingredients not proven as effective
  • No specific enzyme strains

FODMATE by Microbiome Labs

*Results are based on the Top Market Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

FODMATE by Microbiome Labs is a digestive enzyme supplement that has some strength, but is ultimately last on our list due to a few problems. One of the biggest pros is that it has a high amount of servings per container, which means it should last longer than some other products on the market.

However, there are also some cons to consider. This enzyme supplement has a low diversity of enzyme strains, which means it may not be as effective at breaking down a wide range of food types. This product is also only intended for short-term use, which may not be suitable for those looking for a long-term solution. Finally, the price per serving is relatively high at $0.91, which may not be affordable for everyone.

Overall, if you are looking for a short-term digestive supplement that has a high number of servings per container, FODMATE by Microbiome Labs could be worth considering. However, if you are looking for a product with a wider diversity of enzyme strains or a more affordable price point, there may be other options that are a better fit.

PROS
  • High amount of servings per container
CONS
  • Quick dissolving capsules
  • Low diversity of enzyme strains
  • For short term use
  • Price per serving is high ($0.91/serving)

REFERENCES

  1. Terra, W. R., Ferreira, C., Jordao, B. P., & Dillon, R. J. (1996). Digestive enzymes. In Biology of the insect midgut (pp. 153-194). Springer, Dordrecht.
  2. Whitcomb, D. C., & Lowe, M. E. (2007). Human pancreatic digestive enzymes. Digestive diseases and sciences52(1), 1-17.
  3. Schneeman, B. O., & Gallaher, D. (1985). Effects of dietary fiber on digestive enzyme activity and bile acids in the small intestine. Proceedings of the Society for Experimental Biology and Medicine180(3), 409-414.
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